When Ichigo Momomiya is attending an endangered species exhibit with the crush of her life an incident occurs and she is hit by a mysterious light that transfuses her DNA with the that of the endangered Iriomate wildcat. Ichigo soon discovers that her personality has started become more cat like along with her increased agility and the ability to transform herself into a pink-haired heroine named Mew Ichigo. It soon is revealed to Ichigo that her and four other girls have been chosen to take part of the top-secret Mew Project that was designed to protect Earth from an alien enemy known as Deep Blue.